Blar i forfatter "Ræder, Inger Lin Uttakleiv"

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    • The crystal structure of the N-acetylglucosamine 2-epimerase from Nostoc sp. KVJ10 reveals the true dimer 

      Halsør, Marie-Josée Haglund; Rothweiler, Ulli; Altermark, Bjørn; Ræder, Inger Lin Uttakleiv (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-01-08)
      <i>N</i>-Acetylglucosamine 2-epimerases (AGEs) catalyze the interconversion of <i>N</i>-acetylglucosamine and <i>N</i>-acetylmannosamine. They can be used to perform the first step in the synthesis of sialic acid from <i>N</i>-acetylglucosamine, which makes the need for efficient AGEs a priority. This study presents the structure of the AGE from <i>Nostoc</i> sp. KVJ10 collected in northern Norway, ...

    • Features and structure of a cold active N-acetylneuraminic acid lyase 

      Gurung, Man Kumari; Altermark, Bjørn; Helland, Ronny; Smalås, Arne O.; Ræder, Inger Lin Uttakleiv (Journal article; Peer reviewed, 2019-06-11)
      N-acetylneuraminate lyases (NALs) are enzymes that catalyze the reversible cleavage and synthesis of sialic acids. They are therefore commonly used for the production of these high-value sugars. This study presents the recombinant production, together with biochemical and structural data, of the NAL from the psychrophilic bacterium Aliivibrio salmonicida LFI1238 (AsNAL). Our characterization shows ...

    • Sequence analysis of nonulosonic acid biosynthetic gene clusters in Vibrionaceae and Moritella viscosa 

      Halsør, Marie-Josée Haglund; Altermark, Bjørn; Ræder, Inger Lin Uttakleiv (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-20)
      Nonulosonic acid (NulO) biosynthesis in bacteria is directed by <i>nab</i> gene clusters that can lead to neuraminic, legionaminic or pseudaminic acids. Analysis of the gene content from a set mainly composed of <i>Aliivibrio salmonicida</i> and <i>Moritella viscosa</i> strains reveals the existence of several unique nab clusters, for which the NulO products were predicted. This prediction method ...